What is a ‘musical work’? Reflections on the origins of the ‘work concept’ in western art music

No abstract available

High Percentages of Reclaimed Asphalt Affect the Performance of Asphalt Binder

More than 90 percent of the road and highway network in the United States is paved with asphalt concrete. Maintenance and periodic rehabilitation require a continuous supply of aggregates and asphalt binder, both of which are becoming increasingly scarce and expensive. Recycling and reusing these resources can reduce costs and improve sustainability. The most common recyclable material used in road construction is reclaimed asphalt pavement (RAP), which is milled asphalt surface layers that have been removed from existing pavements before new asphalt overlay is placed. Reclaimed asphalt roofing shingles (RAS) are another potential source of asphalt binder.There is growing interest in allowing significantly higher percentages of RAP and RAS in asphalt mixes used on state and local roadways. However, making this change has raised concerns regarding how these composite binders may influence the performance and durability of asphalt mixes, depending on the blends of different virgin and reused binders. Researchers at the UC Pavement Research Center investigated the use of higher percentages of RAP and RAS as a partial replacement for the virgin binder in new asphalt mixes and their effect on pavement performance in California. This research brief summarizes findings from that study.View the NCST Project Webpag

Monteverdi, the 1610 Vespers and the beginnings of the modern musical work

The elevated status of Monteverdi’s 1610 Vespers over the last century provides the starting point for an enquiry into which factors render it so durable. In going against the grain of recent attempts to discern the possible liturgical context for its original performance, this study claims that the collection as a whole (components of which undoubtedly had liturgical origins) can only be exemplary. Moreover, Monteverdi, in his intense engagement with the impersonation of liturgical chanting, has effectively rendered it the analogue of an actual service. Several features suggest that he is capturing something of the listening experience of a liturgy, complete with its distortions and memories. As a collection that is ‘about’ Vespers and which doubles the experience one might be having, this has something in common with the ‘musical work’ as defined by later classical practice, and its very religiosity resonates with the secularized ideology of musical autonomy

What is a ‘musical work’? Reflections on the origins of the ‘work concept’ in western art music

No abstract available

Greenhouse Gas Reduction Opportunities for Local Governments: A Quantification and Prioritization Framework

Local governments have steadily increased their initiative to address global climate change, and many present their proposed strategies through climate action plans (CAPs). This study conducts a literature review on current local approaches to greenhouse gas (GHG) reduction strategies by assessing CAPs in California and presents common strategies in the transportation sector along with useful tools. One identified limitation of many CAPs is the omission of quantitative economic cost and emissions data for decision-making on the basis of cost-effectiveness. Therefore, this study proposes a framework for comparing strategies based on their life cycle emissions mitigation potential and costs. The results data can be presented in a marginal abatement cost curve (MACC) to allow for side-by-side comparison of considered strategies. Researchers partnered with Yolo and Unincorporated Los Angeles Counties to analyze 7 strategies in the transportation and energy sectors (five and two, respectively). A MACC was subsequently developed for each county. Applying the life cycle approach revealed strategies that had net cost savings over their life cycle, indicating there are opportunities for reducing emissions and costs. The MACC also revealed that some emissions reduction strategies in fact increased emissions on a life cycle basis. Applying the MACC framework to two case study jurisdictions illustrated both the feasibility and challenges of including quantitative analysis in their decision-making process. An additional barrier to using the MACC framework in the context of CAPs, is the mismatch between a life cycle and annual accounting basis for GHG emissions. Future work could explore more efficient data collection, alternative scopes of emissions for reporting, and environmental justice concerns.View the NCST Project Webpag

Fateful Aspects of Aspiration among Graduates in New York and Los Angeles

Fateful Aspects of Aspiration among Graduates in New York and Los Angele

Upregulation of Transglutaminase andε(γ-Glutamyl)-Lysine in the Fisher-Lewis Rat Model of Chronic Allograft Nephropathy

Background. Tissue transglutaminase (TG2), a cross-linking enzyme, modulates deposition of extracellular matrix protein in renal fibrosis. This study aimed to examine TG2 and its cross-link product ε(γ-glutamyl)-lysine in the Fisher-Lewis rat renal transplantation (RTx) model of chronic allograft nephropathy (CAN). Materials and Methods. Left renal grafts from male Fisher and Lewis were transplanted into Lewis rats, generating allografts and isografts, respectively. Blood pressure, renal function, and proteinuria were monitored for up to 52 weeks. At termination, CAN was assessed in the renal tissue by light and electron microscopy, TG2 and ε(γ-glutamyl)-lysine by immunofluorescence, and the urinary ε(γ-glutamyl)-lysine by high performance liquid chromatography. Results. Compared to the isograft, the allografts were hypertensive, proteinuric, and uraemic and developed CAN. Extracellular TG2 (glomerulus: 64.55 + 17.61 versus 2.11 + 0.17, P<0.001; interstitium: 13.72 + 1.62 versus 3.19 + 0.44, P<0.001), ε(γ-glutamyl)-lysine (glomerulus: 21.74 + 2.71 versus 1.98 + 0.37, P<0.01; interstitium: 37.96 + 17.06 versus 0.42 + 0.11, P<0.05), TG2 enzyme activity (1.09 + 0.13 versus 0.41 + 0.03 nmol/h/mg protein, P<0.05), TG2 mRNA (20-fold rise), and urinary ε(γ-glutamyl)-lysine (534.2 + 198.4 nmol/24 h versus 57.2 + 4.1 nmol/24 h,P<0.05) levels were significantly elevated in the allografts and showed a positive linear correlation with tubulointerstitial fibrosis. Conclusion. CAN was associated with upregulation of renal TG2 pathway, which has a potential for pharmacological intervention. The elevated urinary ε(γ-glutamyl)-lysine, measured for the first time in RTx, is a potential biomarker of CA

James Young: Scottish industrialist and philanthropist

Abstract available : p. [1-3

The Crystal Structure of the Extracellular 11-heme Cytochrome UndA Reveals a Conserved 10-heme Motif and Defined Binding Site for Soluble Iron Chelates

Members of the genus Shewanella translocate deca- or undeca-heme cytochromes to the external cell surface thus enabling respiration using extracellular minerals and polynuclear Fe(III) chelates. The high resolution structure of the first undeca-heme outer membrane cytochrome, UndA, reveals a crossed heme chain with four potential electron ingress/egress sites arranged within four domains. Sequence and structural alignment of UndA and the deca-heme MtrF reveals the extra heme of UndA is inserted between MtrF hemes 6 and 7. The remaining UndA hemes can be superposed over the heme chain of the decaheme MtrF, suggesting that a ten heme core is conserved between outer membrane cytochromes. The UndA structure has also been crystallographically resolved in complex with substrates, an Fe(III)-nitrilotriacetate dimer or an Fe(III)-citrate trimer. The structural resolution of these UndA-Fe(III)-chelate complexes provides a rationale for previous kinetic measurements on UndA and other outer membrane cytochromes